Mycosis is an infectious disease caused by pathogenic fungus in humans and animals. Mycoses are common and a variety of environmental and physiological conditions can contribute to the development of fungal diseases. Inhalation of fungal spores or localized colonization of the skin may initiate persistent infections; therefore, mycoses often start in the lungs or on the skin.
A fungal infection of the skin was the 4th most common skin disease in 2010 affecting 984 million people. An estimated 1.6 million people die each year of fungal infections.
Individuals being treated with antibiotics are at higher risk of fungal infections.
People with weakened immune systems are also at risk of developing fungal infections. This is the case of people with HIV/AIDS, people under steroid treatments, and people taking chemotherapy. People with diabetes also tend to develop fungal infections. Very young and very old people, also, are groups at risk. Although all are at risk of developing fungal infections, the likelihood is higher in these groups.
Children whose immune systems are not functioning properly (such as children with cancer) are at risk of invasive fungal infections. Antifungal medications can be given at the development of a fever or when an infection has been formally identified. These agents appear equally efficacious. Research suggests kidney damage was less likely with a lipid preparation of amphotericin C compared with conventional amphotericin B. No significant differences were observed in children when comparing other antifungal agents.
Mycoses are medically classified according to the tissue levels initially colonized.
Superficial mycoses are limited to the outermost layers of the skin and hair.
An example of such a fungal infection is Tinea versicolor, a fungus infection that commonly affects the skin of young people, especially the chest, back, and upper arms and legs. Tinea versicolor is caused by a fungus that lives in the skin of some adults. It does not usually affect the face. This fungus produces spots that are either lighter than the skin or a reddish brown. This fungus exists in two forms, one of them causing visible spots. Factors that can cause the fungus to become more visible include high humidity, as well as immune or hormone abnormalities. However, almost all people with this very common condition are healthy.
Cutaneous mycoses extend deeper into the epidermis, and also include invasive hair and nail diseases. These diseases are restricted to the keratinized layers of the skin, hair, and nails. Unlike the superficial mycoses, host immune responses may be evoked resulting in pathologic changes expressed in the deeper layers of the skin. The organisms that cause these diseases are called dermatophytes, the resulting diseases are often called ringworm, dermatophytosis or tinea. Dermatophytes only cause infections of the skin, hair, and nails, and are unable to induce systemic, generalized mycoses, even in immunocompromised hosts.
Subcutaneous mycoses involve the dermis, subcutaneous tissues, muscle and fascia. These infections are chronic and can be initiated by piercing trauma to the skin which allows the fungi to enter. These conditions are difficult to treat and may require surgical intervention such as debridement
Systemic mycoses due to primary pathogens
Systemic mycoses due to primary pathogens originate normally in the lungs and may spread to other organ systems. Organisms that cause systemic mycoses are inherently virulent. In general, primary pathogens that cause systemic mycoses are dimorphic.
Systemic mycoses due to opportunistic pathogens
Systemic mycoses due to opportunistic pathogens are infections of patients with immune deficiencies who would otherwise not be infected. Examples of immunocompromised conditions include AIDS, alteration of normal flora by antibiotics, immunosuppressive therapy, and metastatic cancer. Examples of opportunistic mycoses include Candidiasis, Cryptococcosis and Aspergillosis.
Keeping the skin clean and dry, as well as maintaining good hygiene, will help larger topical mycoses. Because fungal infections are contagious, it is important to wash after touching other people or animals. Sports clothing should also be washed after use.
Topical and systemic antifungal drugs are used to treat mycoses.
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